I see this question on February 2 - I too have this problem in Reader 8 (on my home computer). When I open any PDF document (I do not create any documents) I receive a message saying to wait until the document is optimized for reading. This message does not appear on my work computer using Reader version 7 (again, I do not create PDF documents on my work computer). I do not use a screen reader on either machine, and don't believe I have any accessibility features turned on for my PC (home or work). It started on my home PC when I still had version 7 and continues now that I upgraded to version 8 (I thought I might have an option to turn this feature off when I upgraded, but no such luck). I don't have a true problem with this optimization, but it is annoying to have to wait for documents to open, etc. and not need this feature's capabilities.
Leonard
Leonard Rosenthol
PDF Standards Architect
Adobe Systems