A friend had me look at her Vista PC because of the 20 icons on her desktop, 16 of them had the familiar Adobe Reader icon, instead of their normal icons. Whenever one of those icons would be selected we would get a message that Adobe reader could not open the file. And it wasn't just desktop icons - almost anything we selected brought up that message - Interner Explorer, msconfig, Windows Explorer, System Restore, MS Word, AVG to name a few of the many. I even went to Start/Run and entered '%SystemRoot%\system32\restore\rstrui.exe', and got the same result.
Task manager DID work, and every time we would get one of those messages, we could see that Acrord32.exe was running. We could kill that process, but it would just pop up next time we tried to open almost anything.
I ultimately uninstalled all Adobe products from her PC, and everything went back to working normally. However, she's a school teacher and need Adobe reader for her job, so the next day I went back to her place, went to Adobe's site and downloaded the newest version of Adobe Reader.
All her icons reverted back to the Adobe Reader picture and we, once again, could not open anything. So I again uninstalled the reader, saw that the icons were correct, and that everyhing worked as it should.
How do I fix this so she can have Adobe Reader back on her PC?
1) Install Reader again
2) By now, you should see all Reader file icons again as well
3) Select a file you know that should open with a known application on her workstation > right-click to bring up the sub-menu > select Open With > check "always open with..." option and pick the correct applicationYou are basically re-associating file with an application this way. If you pick the wrong program, just try again and pick a different one.
Hope this helps.