The 10.1.1 update to Acrobat X and Adobe Reader X on Sep 13 2011 introduces a number of workflow-critical changes to the folder locations and persistent variable storage methods used by both products on Windows and Mac, and users who have scripts in the user-context JavaScript folders, or who rely on global persistent variables, will be affected by the change and must take action. I've summarized the pertinent details here.
For in-depth information on application security models in Acrobat and Adobe Reader, see the Application Security Library at ADC, which has been updated to reflect the 10.1.1 patch.
Note that as of right now, the Acrobat Administrator's Information Manager (AIM) app has not been updated.
;-)
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