Best scan settings for newspaper clipping, to use both text and photos?

Hello, I hope to get some opinions and help about the best settings to use to scan in about 3000 pages of material. I'd like to do it ONCE and then be able to use it in the future in a variety of ways.
 
Question: What are the best Acrobat X Pro Windows 7 settings to use, and what process/order should I do all this in? Lots of steps, so scanning right appears to really important.
 
The material is Applications for a Historical Society. Some were generated back in the early 80's using typewriters. Each person's application is about 10-30 pages long. These black and white copies include a xeroxed copy of:
 
* A professional headshot (about 3x5 or 4x6)
* A typed application, including some straight black line lines.
* Newspaper clippings about the person, including both pictures and text
* Other biographical information such as resumes, recommendations etc.
 
I am building a website for this, each person will have a page, and would like to be able to:
 
* Have a separate searchable PDF file for each person (not all of it will be searchable, especially some of the newspaper articles)
* Capture parts of the text I can and edit in Word to include directly on the site
* Crop and use parts of the PDFs (like a single article)
* Crop,fix and use all the photos including the newspaper ones
 
I have read some big differences in opinions about what to do since it is mixed media. What presets? Color/autoselect/bw/grayscale? 300 or 600? TIFF or PDF? Optimization options? Filters? And any other settings or steps you can suggest would be great.
 
Thanks in advance!